Markus Hüllebrand

Publications

2024

Baeßler B, Engelhardt S, Hekalo A, Hennemuth A, Hüllebrand M, Laube A, Scherer C, Tölle M, Wech T (2024) Perfect Match: Radiomics and Artificial Intelligence in Cardiac Imaging. Circ: Cardiovascular Imaging 17(6)

Hottenrott S, Bendz P, Meybohm P, Bauer E, Schmee S, Haas T, Kranke P, Rumpf F, Helmer P, Hennemuth A, Westphal M, Alpers R, Hüllebrand M, Börm P, Blanck N, Zacharowski K, Vo L, Booms P, Ghanem A, Wolfram C, Yürek F, Salgado E, Spies C, Balzer F, Flothow A, Sundmacher L, König A, Schüttig W, von Dincklage F, Nagel SK, Heilinger J-C (2024) KI-augmentierte perioperative klinische Entscheidungsunterstüt- zung (KIPeriOP) – Studiendesign und erste Zwischenergebnisse. Anästh Intensivmed 65:156–172

Ivantsits M, Tautz L, Huellebrand M, Walczak L, Akansel S, Khasyanova I, Kempfert J, Sündermann S, Falk V, Hennemuth A (2024) MV-GNN: Generation of continuous geometric representations of mitral valve motion from 3D+t echocardiography. Computers in Biology and Medicine 182:109154

Manini C, Hüllebrand M, Walczak L, Nordmeyer S, Jarmatz L, Kuehne T, Stern H, Meierhofer C, Harloff A, Erley J, Kelle S, Bannas P, Trauzeddel RF, Schulz-Menger J, Hennemuth A (2024) Impact of training data composition on the generalizability of convolutional neural network aortic cross-section segmentation in four-dimensional magnetic resonance flow imaging. Journal of Cardiovascular Magnetic Resonance 26(2):101081

Rahlfs H, Hüllebrand M, Schmitter S, Strecker C, Harloff A, Hennemuth A (2024) Learning carotid vessel wall segmentation in black blood MRI using sparsely sampled cross-sections from 3D data. Proceedings of SPIE Medical Imaging: Computer-Aided Diagnosis. 129271P

2023

Loose S, Solou D, Strecker C, Hennemuth A, Hüllebrand M, Grundmann S, Asmussen A, Treppner M, Urbach H, Harloff A (2023) Characterization of aortic aging using 3D multi-parametric MRI-long-term follow-up in a population study. Sci Rep 13(1)

Martín-Isla C, Campello VM, Izquierdo C, Kushibar K, Sendra-Balcells C, Gkontra P, Sojoudi A, Fulton MJ, Arega TW, Punithakumar K, Li L, Sun X, Al Khalil Y, Liu D, Jabbar S, Queirós S, Galati F, Mazher M, Gao Z, Beetz M, Tautz L, Galazis C, Varela M, Hüllebrand M, Grau V, Zhuang X, Puig D, Zuluaga MA, Mohy-ud-Din H, Metaxas D, Breeuwer M, van der Geest RJ, Noga M, Bricq S, Rentschler ME, Guala A, Petersen SE, Escalera S, Palomares JFR, Lekadir K (2023) Deep Learning Segmentation of the Right Ventricle in Cardiac MRI: The M&Ms Challenge. IEEE J. Biomed. Health Inform. 27(7):3302–3313

Schafstedde M, Jarmatz L, Brüning J, Hüllebrand M, Nordmeyer S, Harloff A, Hennemuth A (2023) Population-based reference values for 4D flow MRI derived aortic blood flow parameters. Physiol. Meas. 44(3):035003

2022

Hennemuth A, Hüllebrand M, Doeblin P, Krüger N, Kelle S (2022) Utilization of artificial intelligence in diagnostic cardiac imaging analysis. Kardiologe 16(2):72–81

Huellebrand M, Ivantsits M, Tautz L, Kelle S, Hennemuth A (2022) A Collaborative Approach for the Development and Application of Machine Learning Solutions for CMR-Based Cardiac Disease Classification. Front Cardiovasc Med 9

Ivantsits M, Goubergrits L, Kuhnigk J-M, Huellebrand M, Bruening J, Kossen T, Pfahringer B, Schaller J, Spuler A, Kuehne T, Jia Y, Li X, Shit S, Menze B, Su Z, Ma J, Nie Z, Jain K, Liu Y, Lin Y, Hennemuth A (2022) Detection and analysis of cerebral aneurysms based on X-ray rotational angiography – the CADA 2020 challenge. Med Image Anal 77:102333

Krüger N, Meyer A, Tautz L, Hüllebrand M, Wamala I, Pullig M, Kofler M, Kempfert J, Sündermann S, Falk V, Hennemuth A (2022) Cascaded neural network-based CT image processing for aortic root analysis. Int J CARS 17:507–519

Lalande A, Chen Z, Pommier T, Decourselle T, Qayyum A, Salomon M, Ginhac D, Skandarani Y, Boucher A, Brahim K, de Bruijne M, Camarasa R, Correia TM, Feng X, Girum KB, Hennemuth A, Huellebrand M, Hussain R, Ivantsits M, Ma J, Meyer C, Sharma R, Shi J, Tsekos NV, Varela M, Wang X, Yang S, Zhang H, Zhang Y, Zhou Y, Zhuang X, Couturier R, Meriaudeau F (2022) Deep learning methods for automatic evaluation of delayed enhancement-MRI. The results of the EMIDEC challenge. Med Image Anal 79:102428

Sieren MM, Balks MF, Schlueter JK, Wegner F, Huellebrand M, Scharfschwerdt M, Barkhausen J, Frydrychowicz A, Gabbert DD, Oechtering TH (2022) Comprehensive analysis of haemodynamics in patients with physiologically curved prostheses of the ascending aorta. Eur J Cardiothorac Surg 62(1):ezab352

2021

Ivantsits M, Goubergrits L, Kuhnigk JM, Huellebrand M, Brüning J, Kossen T, Pfahringer B, Schaller J, Spuler A, Kuehne T, Hennemuth A (2021) Cerebral Aneurysm Detection and Analysis Challenge 2020 (CADA). In: Hennemuth A, Goubergrits L, Ivantsits M, Kuhnigk JM (eds) Cerebral Aneurysm Detection and Analysis. CADA 2020. LNCS 12643, pp 3–17

Ivantsits M, Huellebrand M, Kelle S, Kuehne T, Hennemuth A (2021) Intracranial Aneurysm Rupture Risk Estimation Utilizing Vessel-Graphs and Machine Learning. In: Hennemuth A, Goubergrits L, Ivantsits M, Kuhnigk JM (eds) Cerebral Aneurysm Detection and Analysis. CADA 2020. LNCS 12643, pp 93–103

Ivantsits M, Kuhnigk J-M, Huellebrand M, Kuehne T, Hennemuth A (2021) Deep Learning-Based 3D U-Net Cerebral Aneurysm Detection. In: Hennemuth A, Goubergrits L, Ivantsits M, Kuhnigk JM (eds) Cerebral Aneurysm Detection and Analysis. CADA 2020. LNCS 12643, pp 31–38

2020

Huellebrand M, Messroghli D, Tautz L, Kuehne T, Hennemuth A (2020) An Extensible Software Platform for Interdisciplinary Cardiovascular Imaging Research. Comput Methods Programs Biomed 184:105277

Kharabish A, Belker K, Martinoff S, Ewert P, Hennemuth A, Huellebrand M, Stern H, Meierhofer C (2020) Intraindividual validation of 4D flow measurement against 2D flow measurements in complex flow patterns in routine clinical cardiovascular magnetic resonance of bicuspid aortic valve. Egypt J Radiol Nucl Med 51:222

Oechtering TH, Sieren MM, Hunold P, Hennemuth A, Huellebrand M, Scharfschwerdt M, Richardt D, Sievers H-H, Barkhausen J, Frydrychowicz A (2020) Time-resolved 3-dimensional magnetic resonance phase contrast imaging (4D Flow MRI) reveals altered blood flow patterns in the ascending aorta of patients with valve-sparing aortic root replacement. J Thorac Cardiovasc Surg 159(3):798–810

Sieren MM, Schultz V, Fujita B, Wegner F, Huellebrand M, Scharfschwerdt M, Sievers H-H, Barkhausen J, Frydrychowicz A, Oechtering TH (2020) 4D flow CMR analysis comparing patients with anatomically shaped aortic sinus prostheses, tube prostheses and healthy subjects introducing the wall shear stress gradient: a case control study. J Cardiovasc Magn Reson 22:59

Tautz L, Zhang H, Hüllebrand M, Ivantsits M, Kelle S, Kuehne T, Falk V, Hennemuth A (2020) Cardiac radiomics: an interactive approach for 4D data exploration. Curr Dir Biomed Eng 6(1):20200008

Walczak L, Goubergrits L, Hüllebrand M, Georgii J, Falk V, Hennemuth A (2020) Using position-based dynamics to simulate deformation in aortic valve replacement procedure. Curr Dir Biomed Eng 6(1):20200042

2019

Hennemuth A, Kuhnigk JM, Steinmetz M, Kelle S, Chitiboi T, Frahm J, Huellebrand M (2019) Automatic Analysis of Multicycle Real-time MRI for the Assessment of Variable Cardiac Function based on Multi-orientation U-net Segmentation. Proceedings of the 27th Annual Meeting ISMRM. 2127

Neugebauer M, Tautz L, Hüllebrand M, Sündermann S, Degener F, Goubergrits L, Kühne T, Falk V, Hennemuth A (2019) Virtual downsizing for decision support in mitral valve repair. Int J CARS 14(2):357–371

2018

Kaufhold L, Krafft A, Strecker C, Huellebrand M, Ludwig U, Harloff A, Hennemuth A (2018) Automatic carotid vessel wall assessment based on a combined analysis of TOF-MR angiography and MSD T2-weighted MRI sequences. Proceedings of the Joint Annual Meeting of the ISMRM and the ESMRMB. 1885

Oechtering T, Schlueter J, Sieren M, Scharfschwerdt M, Auer C, Huellebrand M, Sievers H-H, Barkhausen J, Frydrychowicz A (2018) 4D-Flow-MRI analysis of aortic flow patterns after replacement of the ascending aorta with a physiologically pre-shaped, 90° bent prosthesis. Proceedings of the Joint Annual Meeting of the ISMRM and the ESMRMB. 0006

Tautz L, Neugebauer M, Hüllebrand M, Vellguth K, Degener F, Sündermann S, Kuehne T, Falk V, Hennemuth A (2018) Extraction of Open-State Mitral Valve Geometry from CT Volumes. International Journal of Computer Assisted Radiology and Surgery

Tautz L, Neugebauer M, Hüllebrand M, Vellguth K, Degener F, Sündermann S, Wamala I, Goubergrits L, Kuehne T, Falk V, Hennemuth A (2018) Extraction of open-state mitral valve geometry from CT volumes. Int J CARS 13(11):1741–1754

2017

Tautz L, Hüllebrand M, Steinmetz M, Voit D, Frahm J, Hennemuth A (2017) Exploration of Interventricular Septum Motion in Multi-Cycle Cardiac MRI. In: Bruckner S, Hennemuth A, Kainz B, Hotz I, Merhof D, Rieder C (eds) VCBM 17: Eurographics Workshop on Visual Computing for Biology and Medicine. The Eurographics Association, pp 169–178

Zoehrer F, Huellebrand M, Chitiboi T, Oechtering T, Sieren M, Frahm J, Hahn HK, Hennemuth A (2017) Real-time myocardium segmentation for the assessment of cardiac function variation. Proceedings of SPIE Medical Imaging: Biomedical Applications in Molecular, Structural, and Functional Imaging. 101370L:pp 1–7

2016

Huellebrand M, Neugebauer M, Steinmetz M, Frahm J, Hennemuth A (2016) Quantitative Assessment of Functional Variability with Real-time MRI. Proceedings of the 24th Annual Meeting ISMRM. 2631

Oechtering TH, Hons CF, Sieren M, Hunold P, Hennemuth A, Huellebrand M, Drexl J, Scharfschwerdt M, Richardt D, Sievers H-H, Barkhausen J, Frydrychowicz A (2016) Time-resolved 3-dimensional magnetic resonance phase contrast imaging (4D Flow MRI) analysis of hemodynamics in valve-sparing aortic root repair with an anatomically shaped sinus prosthesis. J Thorac Cardiovasc Surg 152(2):418–427

2015

Chitiboi T, Hennemuth A, Tautz L, Huellebrand M, Frahm J, Hahn HK (2015) Automatic multi-cycle analysis of cardiac function from real-time MRI. Proc. of 18th Annual SCMR Scientific Sessions. P 385

Huellebrand M, Hennemuth A, Tautz L, Joseph A, Frahm J (2015) Analysis of aortic blood-flow from ECG-free realtime PC MRI. Proc. of 18th Annual SCMR Scientific Sessions. Q 42

Kharabish A, Meierhofer C, Ewert P, Stern H, Hüllebrand M, Hennemuth A, Fratz S (2015) Intraindividual Validation of 4D Flow Measurement against 2D Flow Measurements in aortas with bicuspid or tricuspid valves by Cardiovascular Magnetic Resonance (CMR). Proc. of 18th Annual SCMR Scientific Sessions. P 216

Oechtering T, Haegele J, Hunold P, Scharfschwerdt M, Huellebrand M, Sievers H-H, Barkhausen J, Frydrychowicz A (2015) 4D Flow MRI: Analysis of Aortic Hemodynamics after Valve-Sparing Aortic Root Replacement with an Anatomically Shaped Sinus Prosthesis. Proceedings of the 23rd Annual Meeting ISMRM. 2725

Oechtering T, Hons C, Hunold P, Hennemuth A, Huellebrand M, Drexl J, Scharfschwerdt M, Richardt D, Sievers H, Barkhausen J, Frydrzchowicz A (2015) Aortic Haemodynamics after Valve-Sparing Aortic Root Replacement with an Anatomically Shaped Sinus Prosthesis Analysed by 4D Flow MRI. 4D Flow Workshop 2015

Untenberger M, Hüllebrand M, Tautz L, Joseph AA, Voit D, Merboldt KD, Frahm J (2015) Spatiotemporal phase unwrapping for real-time phase-contrast flow MRI: Phase Unwrapping for Real-Time Flow MRI. Magn Reson Med 74(4):964–970

2014

Chitiboi T, Hennemuth A, Tautz L, Huellebrand M, Frahm J, Hahn HK (2014) Cardiac Function Analysis in Multi-cycle Real-time MRI. Proceedings of the Joint Annual Meeting ISMRM-ESMRMB. 3929

Chitiboi T, Hennemuth A, Tautz L, Hüllebrand M, Frahm J, Linsen L, Hahn HK (2014) Context-Based Segmentation and Analysis of Multi-Cycle Real-Time Cardiac MRI. Proceedings of IEEE International Symposium on Biomedical Imaging. pp 943–946

Hennemuth A, Chitiboi T, Tautz L, Huellebrand M, Braunewell S, Frahm J (2014) Real-Time MRI for the Quantification of Inter-Heartbeat-Variation. Annual Meeting Radiological Society of North America (RSNA). QIRR006

Huellebrand M, Hennemuth A, Messroghli D, Kuehne T (2014) An OsiriX plugin for integrated cardiac image processing research. Proceedings of SPIE Medical Imaging: PACS and Imaging Informatics: Next Generation and Innovations. 90390D:pp 1–7

Rudyanto RD, Kerkstra S, van Rikxoort EM, Fetita C, Brillet PY, Lefevre C, Xue W, Zhu X, Liang J, Oksüz I, Unay D, Kadipaşaoğlu K, Estépar RS, Ross JC, Washko GR, Prieto JC, Hoyos MH, Orkisz M, Meine H, Hüllebrand M, Stöcker C, Mir FL, Naranjo V, Villanueva E, Staring M, Xiao C, Stoel BC, Fabijanska A, Smistad E, Elster AC, Lindseth F, Foruzan AH, Kiros R, Popuri K, Cobzas D, Jimenez-Carretero D, Santos A, Ledesma-Carbayo MJ, Helmberger M, Urschler M, Pienn M, Bosboom DG, Campo A, Prokop M, de Jong PA, Ortiz-de-Solorzano C, Muñoz-Barrutia A, van Ginneken B (2014) Comparing algorithms for automated vessel segmentation in computed tomography scans of the lung: the VESSEL12 study. Med Image Anal 18(7):1217–1232

2013

Drexl J, Mirzaee H, Harloff A, Hüllebrand M, Hennemuth A, Hahn HK (2013) A Software Tool for the Computation of Arterial Pulse Wave Velocities from Flow-sensitive 4D MRI Data. Computing in Cardiology. pp 559–562

Hennemuth A, Friman O, Huellebrand M, Peitgen H-O (2013) Mixture-model-based segmentation of myocardial delayed enhancement in MR image data. Statistical Atlases and Computational Models of the Heart. Imaging and Modelling Challenges. LNCS 7746, pp 87–96

Huellebrand M, Hennemuth A, Frahm J, Tautz L (2013) Automatic Quantification of Blood Flow from Real-time Phase-contrast MRI. Proc. RSNA 2013. pp SSC03–06

2012

Hennemuth A, Friman O, Huellebrand M, Peitgen H-O, Mahnken A (2012) Semi-Automatic Quantification of Late Enhancement in CT and MRI Images. International Society for Magnetic Resonance in Medicine. 1251

Hennemuth A, Knowles B, Huellebrand M, Tautz L, Peitgen H-O (2012) Automatic Detection of Left Atrial Scar Tissue in DE-MRI using a Mixture Model and Location Constraints. cDEMRI Challenge, ISBI 2012. pp 1–2

Messroghli D, Huellebrand M, H-Ici DO, Hennemuth A, Kuehne T (2012) Optimized assessment of both left and right ventricular parameters from multi-slice acquisitions of single orientations using reconstructed 3D cine data. J Cardiovasc Magn Reson 14(1):P289

2011

Hennemuth A, Friman O, Schumann C, Bock J, Drexl J, Huellebrand M, Markl M, Peitgen HO (2011) Fast interactive exploration of 4D MRI flow data. In: Wong KH, et al. (eds) SPIE Medical Imaging. SPIE, 79640E:pp 1–11

Huellebrand M, Hennemuth A, Messroghli D, Kuehne C, Friman O (2011) Semi-Automatic 4D Fuzzy Connectedness Segmentation of Heart Ventricles in Cine MRI. Bildverarbeitung für die Medizin. pp 3–7

Research Interests