Prof. Dr. rer. nat. Matthias Günther

Physicist
Research Scientist
Medical Imaging

Tabbed contents

Recent Publications

2025

Galinovic I, Fiebach JB, Boutitie F, Cheng B, Cho T-H, Ebinger M, Endres M, Enzinger C, Fiehler J, Ford I, Gregori J, Günther M, Lemmens R, Muir KW, Nighoghossian N, Roy P, Simonsen CZ, Thijs VN, Wouters A, Gerloff C, Thomalla G, Pedraza S (2025) Effect of IV Thrombolysis With Alteplase in Patients With Vessel Occlusion in the WAKE-UP Trial. Neurology 104(2):e209871

Hoffmann G, Preibisch C, Günther M, Mahroo A, van Osch MJP, Václavů L, Metz M-C, Jung K, Zimmer C, Wiestler B, Kaczmarz S (2025) Noninvasive blood–brain barrier integrity mapping in patients with high-grade glioma and metastasis by multi–echo time–encoded arterial spin labeling. Magn Reson Med online first

Mahroo A, Buck MA, Konstandin S, Huber J, Hoinkiss DC, Hirsch J, Günther M (2025) New physiological insights using multi-TE ASL MRI measuring blood-brain barrier water exchange after caffeine intake. MAGMA online first

Padrela BE, Slivka M, Sneve MH, Garrido PF, Dijsselhof MBJ, Hageman T, Geier O, Grydeland H, Mahroo A, Kuijer JPA, Konstandin S, Eickel K, Barkhof F, Günther M, Walhovd KB, Fjell AM, Mutsaerts HJMM, Petr J (2025) Blood-brain barrier water permeability across the adult lifespan: a multi-echo ASL study. Neurobiology of Aging 147:176–186

Tee M, Padrela BE, Dupeyron M, Huang J, Low M, Konstandin S, Eickel K, Günther M, Minta K, Schinazi VR, Colombo G, Petr J, Mutsaerts HJMM, Hilal S (2025) Associations between potential risk factors and blood-brain barrier water permeability in middle-aged and older adults. Journal of Alzheimer’s Disease 104(1):95–105

2024

Bamberg F, Schlett CL, Caspers S, Ringhof S, Günther M, Hirsch JG, Rudebusch J, Miklankova P, Bittner N, Jockwitz C, Forsting M, Hosten N, Kaaks R, Kauczor H-U, Kroenke T, Niendorf T, Peters A, Pischon T, Stang A, Berger K, Volzke H (2024) Baseline MRI Examination in the NAKO Health Study-Findings on Feasibility, Participation and Dropout Rates, Comfort, and Image Quality. 587–593

Buck MA, Eickel K, Günther M (2024) Development of a robust velocity selective arterial spin labeling sequence to address B0- and B1-field inhomogeneities for breast imaging. Magn Reson Mater Phy 37(S1):1–781(P412)

Buck MA, Sommer L, Huber J, Günther M, Hoinkiss DC (2024) Finding the optimal acquisition strategy to visualize liver perfusion using velocity selective arterial spin labeling. Proceedings of the 40th Annual Scientific Meeting of the European Society of Magnetic Resonance in Medicine and Biology. Barcelona, Spain, 411

Cetin A, Turhan G, Padrela B, Mahroo A, Konstandin S, Hoinkiss DC, Breutigam NJ, Keil V, Ayca ED, Özduman K, Eickel K, Mutsaerts H, Petr J, Günther M, Dincer A, Ozturk-Isik E (2024) Quantification of BBB Permeability in glioma using ASL with tissue specific T2 values. Proceedings of the ISMRM & ISMRT Annual Meeting & Exhibition. 3862

Cetin AI, Turhan G, Padrela BE, Mahroo A, Konstandin S, Honkiss DC, Breutigam N-J, Keil V, Barkhof F, Danyeli AE, Özduman K, Necmettin Pamir MN, Eickel K, Mutsaerts H-J, Petr J, Günther M, Dincer A, Ozturk-Isik E (2024) Tissue-specific T2 BBB-ASL in Meningiomas. Magn Reson Mater Phy 37(S1):1–781(P416)

See more publications from Matthias Günther

Curriculum Vitae

Joerg Matthias Günther

Degrees

Dr. rer. nat (magna cum laude, Heidelberg University)
Physics Diploma (Heidelberg University)
Postgraduate Education Medical Physics (Heidelberg University)
Prediploma Economic Sciences (Fernuni Hagen)

Scientific Career

03/2016 – 12/2018	Guest Scientist at the University of California, Berkeley, USA
11/2009 – current	Professor of MR-Physics, University of Bremen
11/2009 – current	Head of MR-Imaging, Fraunhofer MEVIS, Bremen
	Member of Management Board, Fraunhofer MEVIS, Bremen
11/2008	Habilitation: "Non-invasive quantitative perfusion measurement in MRI: Efficient preparation and readout strategies for arterial spin labeling ", Faculty Physics, Heidelberg University
07/2004 – current	Executive Director of mediri GmbH, Heidelberg, Deutschland
07/2004 – 10/2009	Group Leader at the Neurological Clinic, University Clinic Mannheim, Heidelberg University, Germany
02/2001 – 07/2004	Senior Scientist at Advanced MRI Technologies, LLC, Sebastopol, CA, USA
11/1999 – 11/2000	Postdoc at Deutsches Krebsforschungszentrum (German Cancer Research Center), Heidelberg, Germany
11/1996 – 11/1999	Doctoral Dissertation: Nicht-invasive Perfusionsmessung mit arterieller Spin-Markierung (german) at Deutsches Krebsforschungszentrum (German Cancer Research Center), Heidelberg, Germany
08/1996 – 11/1996	Scientific Assistant at Max-Planck-Institute for Nuclear Physics, Heidelberg
08/1995 – 08/1996	Diploma, Heidelberg-Moscow ββ-Experiment am LNGS, Assergi, Italy for the Max-Planck-Institute, Heidelberg, Germany
10/1991 – 08/1996	Studies of Physics at Heidelberg University, Germany

Teaching

11/1996 – 11/1999	Teaching Assistant, Physics for Medical classes, Heidelberg University, Heidelberg, Germany
11/1999 – 11/2000	Supervision of graduates and postgraduates at Deutsches Krebsforschungszentrum (German Cancer Research Center), Heidelberg, Germany
1998 – present	Numerous invited teaching courses at universities and laboratories world-wide (~150)
WS 2006/2007	Lecture on “Physical Basics of Medical Imaging” at Heidelberg University, Germany
09/2006	Organizer and tutor of ESMRMB-course “MR lectures on Flow and Perfusion”, Copenhagen, Denmark.
11/2006 – present	Supervision of graduates and postgraduates at Neurological clinic, University hospital Mannheim, Heidelberg University, Germany
05/2007	Lecture on Arterial Spin Labeling at the Joint Meeting of ISMRM and ESMRMB, Berlin, Germany.
10/2007	Organizer and tutor of ESMRMB-course “MR lectures on Perfusion”, Freiburg, Germany.
WS 2007/2008	Lecture on “Physical Basics of Ultrasound Imaging” at MaReCuM, Heidelberg University, Germany
WS 2008/2009	Lecture on “Physical Basics of Ultrasound Imaging” at MaReCuM, Heidelberg University, Germany
SS 2010 - 2015, 2017 - 2020	Lecture on “Physical Basics of Medical Imaging” at University Bremen, Germany
WS 2010/2011	Lecture on “MR-Physics” at University Bremen, Germany
05/2011	Lecture on Arterial Spin Labeling at the annual Meeting of ISMRM, Montreal, Canada.
05/2011	Lecture on Perfusion at the annual Meeting of ISMRM, Montreal, Canada.
SS 2011 - 2012	Lecture on “Physik für Biologen” at University Bremen, Germany
SS 2011 - 2015, 2017 -2020	Lecture on “Experimentalphysik VI: Kerne und Teilchen” at University Bremen, Germany
09/2011	Organizer and tutor of ESMRMB-course “MR lectures on Perfusion”, Oxford, UK.
WS 2011/2012, 2015/2016	Lecture series on “Methoden der Biophysik” at University Bremen, Germany
05/2013	Tutor of “Arterial Spin Labeling for physicians” in Verona, Italy
09/2013	Organizer and tutor of “Arterial Spin Labeling for physicists” in Toulouse, France
06/2017	Organizer and tutor of ESMRMB-course “Lectures on MR - Measurement of perfusion and capillary exchange”, Bremen, Germany
09/2018	Organizer and tutor of ESMRMB-course “Lectures on MR - MR image processing - from image data to information”, Berlin, Germany

Patents / Reviewer

Patents

Translucent Intensity Projection Imaging
Inventors: Oshio, K.; Guenther, M.; Feinberg, D.A.
Filing date: 05/22/2001
US 7020318

Susceptibility Correction and Contrast Encoding with Simultaneously Refocused MR Images
Inventors: Guenther, M.; Feinberg, D.A; Oshio, K.
Filing date: 05/16/2002
WO/2003/098233

Method and Apparatus for Removing Specific Stimulated Echoes in Simultaneous Image Refocusing
Inventors: Guenther, M.; D. A. Feinberg, D.A.
Filing date: 06/15/2002
US 6853188

Efficient Visualization of Cortical Vascular Territories by Cycled Arterial Spin Labeling MRI
Inventors: Guenther, M.
Filing date: 05/20/2005
WO/2006/127687

Extreme Speed-Up Of Acquisition Of Perfusion Time Series By Cycled Arterial Spin Labeling MRI
Inventors: Guenther, M.
Filing date: 09/19/2006
WO/2007/035824

3D motion detection and correction by object tracking in ultrasound images
Inventors: Guenther, M., Bongers, A.
Filing date: 6/29/2009
WO 2010037436 A1

Verfahren und Vorrichtung zur Ermittlung von T2 und T2* mittels MRT
Inventors: Guenther, M., Gregori, J.
Filing date: 04/02/2009
WO2010112215 A1

Ultraschall-Messeinrichtung, Untersuchungsgerät und Verfahren zu deren Betrieb
Inventors: Tretbar, S; Degel, C; Günther, M
Filing date: 12/5/2012
PCT/EP2013/000470

ASL MRI using a sequence of magnetically labeled or unlabeled fluid boli
Inventors: von Samson-Himmelstjerna, F.; Günther, M
Filing date: 03/27/2014
WO 2015144768 A1

Imaging system for generating a series of image
Inventors: Braeutigam, N; von Samson-Himmelstjerna, F.; Günther, M,
Filing date: 4/20/2016,
WO002017182575A1

System, method and computer program for magnetic resonance scanners: Calculation flow
Inventors: Cordes, C.; Porter, D.; Archipovas, S.; Günther, M.
Filing date: 4/20/2016,
WO002017182579A1

Rekonstruktion von Ultraschalldaten mittels neuronaler Netzwerke
Inventor: Günther, M.
Filing date: 11/09/2017
PCT/EP2018/080495

Magnetic resonance imaging system
Inventor: Günther, M.
Filing date: 05/03/2018
DE 10 2018 110 826.5

Cable Mantle/Jacket for shield current suppression
Inventor: Betancourt, D; Bertuch, T; Jenne,J; Günther, M.
Filing date: 11/29/2019
submitted

Reviewer for

(selection, since 2001):

European Commission, COST organization, European Research Council, Deutsche Forschungsgemeinschaft (DFG), Schweizer Nationalfond (SNF), Alexander von Humboldt-Stiftung, Deutscher Akademischer Auslandsdienst (DAAD),Research Promotion Foundation (RPF) of Cyprus, Poland - National Centre for Research and Development

Magnetic Resonance in Medicine, IEEE Transaction for Medical Imaging, Cerebrovascular Diseases, Journal of Magnetic Resonance Imaging, Journal of Neuroscience Methods, Journal of Neuroimaging, Journal of Neurology, Neurosurgery & Psychiatry, Kidney International, Zeitschrift für Medizinische Physik, Magnetic Resonance Materials in Physics Biology and Medicine, NeuroImage, Neuroradiodiology, Biomedical Signal Processing and Control, Applied Sciences, IPMI, MICCAI, ISMRM, ESMRMB