Fraunhofer Institute for Digital Medicine MEVIS- Modeling and Simulation
- Computational Pathology
Dr. Lars Ole Schwen
Publications
2024
Zerbe N, Schwen LO, Geißler C, Wiesemann K, Bisson T, Boor P, Carvalho R, Franz M, Jansen C, Kiehl TR, Lindequist B, Pohlan NC, Schmell S, Strohmenger K, Zakrzewski F, Plass M, Takla M, Küster T, Homeyer A, Hufnagl P (2024) Joining forces for pathology diagnostics with AI assistance: The EMPAIA initiative. Journal of Pathology Informatics 100387
2023
Budelmann D, Qing C, Laue HOA, Albadry M, Dahmen U, Schwen LO (2023) Segmentation of Lipid Droplets in Histological Images. MIDL
Ho H, Rezania V, Schwen LO (2023) Editorial: Multiscale modeling for the liver. Front Bioeng Biotechnol 11:1179980
Jansen C, Lindequist B, Strohmenger K, Romberg D, Küster T, Weiss N, Franz M, Schwen LO, Evans T, Homeyer A, Zerbe N (2023) The vendor-agnostic EMPAIA platform for integrating AI applications into digital pathology infrastructures. Future Generation Computer Systems 140:209–224
Schwen LO, Kiehl TR, Carvalho R, Zerbe N, Homeyer A (2023) Digitization of Pathology Labs: A Review of Lessons Learned. Lab Invest 103(11):100244
2022
Albadry M, Höpfl S, Ehteshamzad N, König M, Böttcher M, Neumann J, Lupp A, Dirsch O, Radde N, Christ B, Christ M, Schwen LO, Laue H, Klopfleisch R, Dahmen U (2022) Periportal steatosis in mice affects distinct parameters of pericentral drug metabolism. Sci Rep 12(21825)
Budelmann D, Laue H, Weiss N, Dahmen U, D’Alessandro LA, Biermayer I, Klingmüller U, Ghallab A, Hassan R, Begher-Tibbe B, Hengstler JG, Schwen LO (2022) Automated Detection of Portal Fields and Central Veins in Whole-Slide Images of Liver Tissue. J Pathol Inform 13:100001
Homeyer A, Geißler C, Schwen LO, Zakrzewski F, Evans T, Strohmenger K, Westphal M, Bülow RD, Kargl M, Karjauv A, Munné-Bertran I, Retzlaff CO, Romero-López A, Sołtysiński T, Plass M, Carvalho R, Steinbach P, Lan YC, Bouteldja N, Haber D, Rojas-Carulla M, Vafaei Sadr A, Kraft M, Krüger D, Fick R, Lang T, Boor P, Müller H, Hufnagl P, Zerbe N (2022) Recommendations on compiling test datasets for evaluating artificial intelligence solutions in pathology. Mod Pathol 35:1759–1769
Schwen LO, Schacherer D, Geißler C, Homeyer A (2022) Evaluating generic AutoML tools for computational pathology. Inform Med Unlocked 29:100853
2021
Homeyer A, Lotz J, Schwen LO, Weiss N, Romberg D, Höfener H, Zerbe N, Hufnagl P (2021) Artificial intelligence in pathology: From prototype to product. J Pathol Inform 12(1):13
2020
Georgii J, Pätz T, Rieder C, Ballhausen H, Schwenke M, Schwen LO, Haase S, Preusser T (2020) Efficient GPU-Based Numerical Simulation of Cryoablation of the Kidney. In: Miller K, Wittek A, Joldes G, Nash M, Nielsen P (eds) Computational Biomechanics for Medicine. Springer, Cham, pp 171–193
Rieder C, Schwenke M, Pätz T, Georgii J, Ballhausen H, Schwen LO, Haase S, Preusser T (2020) Evaluation of a numerical simulation for cryoablation – comparison with bench data, clinical kidney and lung cases. Int J Hyperthermia 37(1):1268–1278
Schwen LO (2020) Ten simple rules for typographically appealing scientific texts. PLOS Computational Biology 16(12):e1008458
2018
Homeyer A, Hammad S, Schwen LO, Dahmen U, Höfener H, Gao Y, Dooley S, Schenk A (2018) Focused scores enable reliable discrimination of small differences in steatosis. Diagn Pathol 13(76):1–9
Schwen LO, Rueschenbaum S (2018) Ten quick tips for getting the most scientific value out of numerical data. Plos Comp Biol 14(10):e1006141
Schwen LO, Andersson A, Korski K, Weiss N, Haase S, Gaire F, Hahn HK, Homeyer A, Grimm O (2018) Data-Driven Discovery of Immune Contexture Biomarkers. Front Oncol 8(627):1–15
2017
Christ B, Dahmen U, Herrmann K-H, König M, Reichenbach JR, Ricken T, Schleicher J, Schwen LO, Vlaic S, Waschinsky N (2017) Computational Modeling in Liver Surgery. Front Physiol 8:906
Schenk A, Ghallab A, Hofmann U, Hassan R, Schwarz M, Schuppert A, Schwen LO, Braeuning A, Teutonico D, Hengstler JG, Kuepfer L (2017) Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage. Sci Rep 7:6224
Schwen LO, Kuepfer L, Preusser T (2017) Modeling approaches for hepatic spatial heterogeneity in pharmacokinetic simulations. Drug Discovery Today: Disease Models 22(2016):35–43
2016
Schwen LO, Homeyer A, Schwier M, Dahmen U, Dirsch O, Schenk A, Kuepfer L, Preusser T, Schenk A (2016) Zonated quantification of steatosis in an entire mouse liver. Comput Biol Med 73:108–118
Xie C, Schwen LO, Wei W, Schenk A, Zafarnia S, Gremse F, Dahmen U (2016) Quantification of Hepatic Vascular and Parenchymal Regeneration in Mice. PLoS ONE 11(8):1–19
Xie C, Wei W, Schenk A, Schwen LO, Zafarnia S, Schwier M, Gremse F, Jank I, Dirsch O, Dahmen U (2016) Visualization of Vascular and Parenchymal Regeneration After 70% Partial Hepatectomy in Normal Mice. JoVE 115(e53935):1–6
2015
Gremse F, Höfter A, Schwen LO, Kiessling F, Naumann U (2015) GPU-Accelerated Sparse Matrix-Matrix Multiplication by Iterative Row Merging. SIAM J Sci Comput 37(1):C54–C71
Saenger C, Schenk A, Schwen LO, Wang L, Gremse F, Zafarnia S, Kiessling F, Xie C, Wei W, Richter B, Dirsch O, Dahmen U (2015) Intrahepatic Vascular Anatomy in Rats and Mice—Variations and Surgical Implications. PLoS ONE 10(11):e0141798
Schwen LO, Pätz T, Preusser T (2015) Some Use Cases for Composite Finite Elements in Image Based Computing. In: Joldes GR, Doyle B, Wittek A, Nielsen PMF, Miller K (eds) MICCAI 2015 Workshop Proceedings Computational Biomechanics for Medicine X. pp 128–140
Schwen LO, Schenk A, Kreutz C, Timmer J, Bartolomé Rodriguez MM, Kuepfer L, Preusser T (2015) Representative Sinusoids for Hepatic Four-Scale Pharmacokinetics Simulations. PLoS ONE 10(7):e0133653
Schwen LO, Wei W, Gremse F, Ehling J, Wang L, Dahmen U, Preusser T (2015) Algorithmically Generated Rodent Hepatic Vascular Trees in Arbitrary Detail. J Theor Biol 365:289–300
2014
Schwen LO, Wolfram U (2014) Validation of Composite Finite Elements Efficiently Simulating Elasticity of Trabecular Bone. Comput Methods Biomech Biomed Engin 17(6):652–660
Schwen LO, Krauss M, Niederalt C, Gremse F, Kiessling F, Schenk A, Preusser T, Kuepfer L (2014) Spatio-Temporal Simulation of First Pass Drug Perfusion in the Liver. PLoS Comput Biol 10(3):e1003499
2012
Schwen LO, Preusser T (2012) Analysis and Algorithmic Generation of Hepatic Vascular Systems. Int J Hepatol 2012(Article ID 357687):1–17
Schwen LO, Pätz T, Preusser T (2012) Composite Finite Element Simulation of Radio Frequency Ablation and Bone Elasticity. In: Eberhardsteiner J, et al (eds) Proceedings of the 6th European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS2012)
2011
Preusser T, Rumpf M, Sauter S, Schwen LO (2011) 3D composite finite elements for elliptic boundary value problems with discontinuous coefficients. SIAM J Sci Comput 33(5):2115–2143